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KMID : 0869619920090040252
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Journal of Korean Society of Hospital Pharmacists
1992 Volume.9 No. 4 p.252 ~ p.255
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Dissolution rate and content uniformity of Chlordiazepoxide·HCI tablets
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Abstract
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Drug effect is depend on bioavailability of preparation and also bioavailability is largely depend on dissolution rate. This study was attempted to evaluate bioavailability of preparations for drug choice among preparations by the dissolution test and content uniformity test of commercial chlordiazepoxide hydrochloride tablets. The dissolution test was conducted in aquas and artificial gastric juice using Basket method with four chlordiazepoxide hydrochloride preparations(A, B, C, D) which were pharmaceutically equivalent. The results were as following : 1) The dissolution rate in aquas was higher in the order of four different brands A>B>D>C. 2) The dissolution rate in artificial gastric juice was higher in the order of four different brands C>B>A>D. 3) Content uniformity of four different brands was better in such order as B>D>C>A. 4) There was no relationship between dissolution rate and content uniformity.
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KEYWORD
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